|
KMID : 0371320080750040255
|
|
Journal of the Korean Surgical Society
2008 Volume.75 No. 4 p.255 ~ p.261
|
|
|
Gemcitabine-based Chemotherapy for Gallbladder Cancer
|
|
Lee Seung-Won
Chung Jun-Chul
Kim Hyung-Chul
Chu Chong-Woo
Jeong Gu-Ae
|
|
|
Abstract
|
|
|
Purpose: Patients with gallbladder cancer tend to have advanced, unresectable tumor at the time of presentation and they face a dismal prognosis in the absence of a standard chemotherapy regimen. This study was performed to evaluate the outcomes of patients with gallbladder cancer and who underwent postoperative gemcitabine-based chemotherapy.
Methods: From March of 2001 to February of 2008, a total of 27 patients underwent operation for gallbladder cancer. They underwent two types of gemcitabine-based chemotherapy. One type of regimen was the combined administration of gemcitabine 1,000 mg/m2 and 5-fluorouracil 200 mg/m2. The other one was combined administration of gemcitabine 1,000 mg/m2 and cisplatin 70 mg/m2.
Results: Among the 27 patients, 15 patients were treated with gemcitabine-based chemotherapy and 12 patients were treated with many kinds of the best supportive care without chemotherapy. The median survival was 29.1±2.7 months and 15.7±2.8 months, respectively. The median survival and disease free survival for the gemcitabine based chemotherapy group who received curative resection was 31.6±2.5 and 15.7±3.2 months, respectively. The median survival and disease free survival for the patients without chemotherapy after curative resection was 16.3±2.9 and 15.7±3.2 months, respectively.
Conclusion: Patients with gallbladder cancer and who received adjuvant gemcitabine-based chemotherapy had a relatively favorable prognosis. Especially, gemcitabine-based combination chemotherapy could be effective and acceptable for the treatment of gallbladder cancer patients who have undergone curative resection. (J Korean Surg Soc 2008;75:255-261)
|
|
|
KEYWORD
|
|
|
Gallbladder cancer, Chemotherapy, Gemcitabine
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|